2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Base Information

Chemical Name:2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate
CAS No.:1268385-08-5
Molecular Formula:C₃₀H₂₄F₅N₅O₅
Molecular Weight:629.543
Hs Code.:

2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Synonyms:2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Suppliers and Price of 2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

There total 15 articles about 2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1268385-05-2
4-(Dimethylamino)butyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

: 111-46-6
diethylene glycol

: 1268385-08-5
2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: With triethylamine; at 40 ℃; for 2h;

Reference yield: 73.0%

: 1268385-07-4
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

: 111-46-6
diethylene glycol

: 1268385-08-5
2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: With triethylamine; In ethyl acetate; at 40 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo4014595

Reference yield:

: 1268385-47-2
2-{3-[4-bromo-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol

: 1268385-08-5
2-[(2-hydroxyethyl)oxy]ethyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5Himidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 55 °C / Inert atmosphere

2.1: periodic acid / acetonitrile / 2 - 20 °C

2.2: 2 - 20 °C

3.1: methanol / 65 °C

4.1: lithium carbonate / N,N-dimethyl-formamide / 0 °C

5.1: hydrogen bromide / ethyl acetate; acetic acid / 0 - 20 °C

6.1: triethylamine / 2 h / 40 °C

With hydrogen bromide; lithium carbonate; periodic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;