2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

Base Information

Chemical Name:2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate
CAS No.:1575836-93-9
Molecular Formula:C₂HF₃O₂*C₁₉H₁₃Cl₂F₄N₃O₂
Molecular Weight:576.255
Hs Code.:

Synonyms:2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

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Chemical Property of 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

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Technology Process of 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

There total 12 articles about 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1575836-90-6
tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1575836-93-9
2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1824-81-3
2-Amino-6-methylpyridine

: 1575836-93-9
2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

Guidance literature:: Multi-step reaction with 12 steps

1.1: periodic acid; iodine; acetic acid; sulfuric acid / water / 6 h / 80 °C

2.1: hydrogenchloride; sodium nitrite / water / 16.5 h / 0 - 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 16 h / 80 °C / Darkness

4.1: calcium carbonate; water / 1,4-dioxane / 10 h / Reflux

5.1: thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: TurboGrignard / tetrahydrofuran / 0.17 h / -20 °C / Inert atmosphere

6.2: 16 h / -20 - 20 °C / Inert atmosphere

7.1: potassium carbonate / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

8.1: sodium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 12 h / 80 °C / 11636.1 Torr / Inert atmosphere; Autoclave

9.1: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -78 °C / Inert atmosphere

10.1: hydroxylamine hydrochloride; sodium acetate / water; methanol / 18 h / 20 °C / Inert atmosphere

11.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 45 °C / Darkness; Inert atmosphere

11.2: 16 h / 20 °C / Darkness; Inert atmosphere

12.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; N-chloro-succinimide; N-Bromosuccinimide; TurboGrignard; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; hydroxylamine hydrochloride; water; iodine; sodium acetate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; periodic acid; calcium carbonate; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 249291-79-0
6-chloro-3-iodo-2-methylpyridine

: 1575836-93-9
2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 16 h / 80 °C / Darkness

2.1: calcium carbonate; water / 1,4-dioxane / 10 h / Reflux

3.1: thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: TurboGrignard / tetrahydrofuran / 0.17 h / -20 °C / Inert atmosphere

4.2: 16 h / -20 - 20 °C / Inert atmosphere

5.1: potassium carbonate / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

6.1: sodium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 12 h / 80 °C / 11636.1 Torr / Inert atmosphere; Autoclave

7.1: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -78 °C / Inert atmosphere

8.1: hydroxylamine hydrochloride; sodium acetate / water; methanol / 18 h / 20 °C / Inert atmosphere

9.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 45 °C / Darkness; Inert atmosphere

9.2: 16 h / 20 °C / Darkness; Inert atmosphere

10.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; N-chloro-succinimide; N-Bromosuccinimide; TurboGrignard; thionyl chloride; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; sodium acetate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;