tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

Base Information

Chemical Name:tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate
CAS No.:1575836-90-6
Molecular Formula:C₂₄H₂₁Cl₂F₄N₃O₄
Molecular Weight:562.348
Hs Code.:

tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

Synonyms:tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

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Chemical Property of tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

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Technology Process of tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

There total 12 articles about tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928783-84-0
1,3-dichloro-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1575836-88-2
tert-butyl 2'-((hydroxyimino)methyl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

: 1575836-90-6
tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

Guidance literature:: tert-butyl 2'-((hydroxyimino)methyl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 45 ℃; for 1h; Darkness; Inert atmosphere;

1,3-dichloro-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene; With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Darkness; Inert atmosphere;

Reference yield:

: 249291-79-0
6-chloro-3-iodo-2-methylpyridine

: 1575836-90-6
tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 16 h / 80 °C / Darkness

2.1: calcium carbonate; water / 1,4-dioxane / 10 h / Reflux

3.1: thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: TurboGrignard / tetrahydrofuran / 0.17 h / -20 °C / Inert atmosphere

4.2: 16 h / -20 - 20 °C / Inert atmosphere

5.1: potassium carbonate / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

6.1: sodium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 12 h / 80 °C / 11636.1 Torr / Inert atmosphere; Autoclave

7.1: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -78 °C / Inert atmosphere

8.1: hydroxylamine hydrochloride; sodium acetate / water; methanol / 18 h / 20 °C / Inert atmosphere

9.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 45 °C / Darkness; Inert atmosphere

9.2: 16 h / 20 °C / Darkness; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; N-chloro-succinimide; N-Bromosuccinimide; TurboGrignard; thionyl chloride; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; sodium acetate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1575836-76-8
tert-butyl 2'-chloro-1H,7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

: 1575836-90-6
tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 12 h / 80 °C / 11636.1 Torr / Inert atmosphere; Autoclave

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -78 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / water; methanol / 18 h / 20 °C / Inert atmosphere

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 45 °C / Darkness; Inert atmosphere

4.2: 16 h / 20 °C / Darkness; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; diisobutylaluminium hydride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;