(2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Base Information

Chemical Name:(2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
CAS No.:106162-90-7
Molecular Formula:C₃₂H₃₄N₂O₇S
Molecular Weight:590.697
Hs Code.:

(2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Synonyms:(2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

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Chemical Property of (2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

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Technology Process of (2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

There total 6 articles about (2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 106162-89-4
(2S,3S,6R,7R)-3-Chloromethyl-7-methoxy-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

: 106162-90-7
(2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Guidance literature:: With silver perchlorate; calcium carbonate; for 1.5h; Ambient temperature;
DOI:10.1021/jm00386a013

Reference yield:

: 68402-81-3
diphenylmethyl 7β-benzamido-7α-methoxy-3-<<(1-methyl-1H-yetrazol-5-yl)thio>methyl>-1-oxadethia-3-cephem-4-carboxylate

: 106162-90-7
(2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 43 percent / acetic acid, magnesium / CH₂Cl₂ / 9 h / 20 °C

2: pyridine, phosphorus pentachloride / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 53.8 percent / pyridine / CH₂Cl₂ / 1.) -20 deg C, 15 min, 2.) 0 deg C, 30 min

4: 100 percent / CH₂Cl₂; ethyl acetate / 2 h / 0 °C

5: 100 percent / calcium carbonate, silver perchlorate / 1.5 h / Ambient temperature

With pyridine; phosphorus pentachloride; silver perchlorate; magnesium; acetic acid; calcium carbonate; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00386a013

Reference yield:

: 68314-03-4
(2R,6R,7R)-7-Amino-7-methoxy-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

: 106162-90-7
(2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 53.8 percent / pyridine / CH₂Cl₂ / 1.) -20 deg C, 15 min, 2.) 0 deg C, 30 min

2: 100 percent / CH₂Cl₂; ethyl acetate / 2 h / 0 °C

3: 100 percent / calcium carbonate, silver perchlorate / 1.5 h / Ambient temperature

With pyridine; silver perchlorate; calcium carbonate; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00386a013