methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate

Base Information

Chemical Name:methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate
CAS No.:431942-38-0
Molecular Formula:C₁₆H₁₃NO₄
Molecular Weight:283.284
Hs Code.:

Synonyms:methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate

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Chemical Property of methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate

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Technology Process of methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate

There total 7 articles about methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 431942-37-9
5-hydroxy-2-methoxy-4-(2-phenylethynyl)pyridine

: 431942-38-0
methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate

Guidance literature:: With sodium acetate; potassium carbonate; copper dichloride; palladium dichloride; at 20 ℃; for 3h;
DOI:10.3987/com-01-9363

Reference yield:

: 51834-97-0
6-methoxypyridine-3-ol

: 431942-38-0
methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / NaH / dimethylformamide / 2 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.58 h / -78 °C

2.2: 86 percent / I₂ / tetrahydrofuran; pentane / 1 h / -78 °C

3.1: 92 percent / (Ph₃P)2PdCl₂; CuI / triethylamine / 4 h / 100 °C

4.1: 77 percent / HCl / tetrahydrofuran / 3 h / 60 °C

5.1: 82 percent / K₂CO₃; AcONa; K₂CO₃ / PdCl₂; CuCl₂ / 3 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butyl lithium; sodium acetate; sodium hydride; potassium carbonate; copper dichloride; palladium dichloride; In tetrahydrofuran; triethylamine; N,N-dimethyl-formamide; pentane;
DOI:10.3987/com-01-9363

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 431942-38-0
methyl 5-methoxy-2-phenylfuro[2,3-c]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: t-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: B(OCH₃)3 / tetrahydrofuran; hexane / 2 h / -78 °C

1.3: 82 percent / peracetic acid / tetrahydrofuran; acetic acid; H₂O / 1 h / -10 °C

2.1: 94 percent / NaH / dimethylformamide / 2 h / 20 °C

3.1: t-BuLi / tetrahydrofuran; pentane / 0.58 h / -78 °C

3.2: 86 percent / I₂ / tetrahydrofuran; pentane / 1 h / -78 °C

4.1: 92 percent / (Ph₃P)2PdCl₂; CuI / triethylamine / 4 h / 100 °C

5.1: 77 percent / HCl / tetrahydrofuran / 3 h / 60 °C

6.1: 82 percent / K₂CO₃; AcONa; K₂CO₃ / PdCl₂; CuCl₂ / 3 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butyl lithium; sodium acetate; sodium hydride; potassium carbonate; copper dichloride; palladium dichloride; In tetrahydrofuran; hexane; triethylamine; N,N-dimethyl-formamide; pentane;
DOI:10.3987/com-01-9363