5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Base Information

Chemical Name:5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide
CAS No.:1427064-19-4
Molecular Formula:C₁₄H₁₀ClF₄N₃O₂
Molecular Weight:363.699
Hs Code.:

Synonyms:5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

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Chemical Property of 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

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Technology Process of 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

There total 5 articles about 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1427064-68-3
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

: 1427064-19-4
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Guidance literature:: With hydrazine hydrate; In ethanol; at 85 ℃; for 5h; Inert atmosphere;

Reference yield:

: 137504-86-0
3-fluoro-4-chlorophenylboronic acid

: 1427064-19-4
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide; toluene; water / 2.5 h / 90 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide; thionyl chloride / 3 h / 75 °C

2.2: 0 - 75 °C

3.1: hydrazine hydrate / ethanol / 5 h / 85 °C / Inert atmosphere

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; hydrazine hydrate; N,N-dimethyl-formamide; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1364678-33-0
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

: 1427064-19-4
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 3 h / 75 °C

1.2: 0 - 75 °C

2.1: hydrazine hydrate / ethanol / 5 h / 85 °C / Inert atmosphere

With thionyl chloride; hydrazine hydrate; N,N-dimethyl-formamide; In ethanol;