5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

Base Information

Chemical Name:5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester
CAS No.:1427064-68-3
Molecular Formula:C₁₅H₁₀ClF₄NO₃
Molecular Weight:363.696
Hs Code.:

Synonyms:5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

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Chemical Property of 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

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Technology Process of 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

There total 4 articles about 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 67-56-1
methanol

: 1364678-33-0
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

: 1427064-68-3
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

Guidance literature:: 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; at 75 ℃; for 3h;

methanol; at 0 - 75 ℃;

Reference yield:

: 67-56-1
methanol

: C₁₄H₇Cl₂F₄NO₂

: 1427064-68-3
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

Guidance literature:: at 0 - 74 ℃;

Reference yield:

: 1211586-75-2
5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

: 1427064-68-3
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide; toluene; water / 2.5 h / 90 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide; thionyl chloride / 3 h / 75 °C

2.2: 0 - 75 °C

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N,N-dimethyl-formamide; In water; N,N-dimethyl-formamide; toluene;