5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Base Information

Chemical Name:5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid
CAS No.:1364678-33-0
Molecular Formula:C₁₄H₈ClF₄NO₃
Molecular Weight:349.669
Hs Code.:

Synonyms:5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Chemical Property:

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Technology Process of 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

There total 2 articles about 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1211586-75-2
5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

: 137504-86-0
3-fluoro-4-chlorophenylboronic acid

: 1364678-33-0
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In water; N,N-dimethyl-formamide; toluene; at 90 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1364678-33-0
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Guidance literature:

Reference yield: 63.0%

: 67-56-1
methanol

: 1364678-33-0
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

: 1427064-68-3
5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

Guidance literature:: 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; at 75 ℃; for 3h;

methanol; at 0 - 75 ℃;