N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

Base Information

Chemical Name:N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide
CAS No.:1612155-87-9
Molecular Formula:C₂₉H₂₈N₄O₄S
Molecular Weight:528.632
Hs Code.:

Synonyms:N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

Chemical Property:

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Technology Process of N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

There total 4 articles about N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₅N₃O₅S

: 2450-71-7
Propargylamine

: 1612155-87-9
N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2014.04.102

Reference yield:

: 92-84-2
10H-phenothiazine

: 1612155-87-9
N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-benzyl-trimethylammonium hydroxide / 2 h / 0 °C / Reflux

2: water; sodium hydroxide / methanol / 15 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

With water; N-benzyl-trimethylammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.102

Reference yield:

: 362-03-8
3-(10H-phenothiazin-10-yl)propanoic acid

: 1612155-87-9
N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.102