N-ISOPROPYL-P-TOLUIDINE

Base Information

• Chemical Name: N-ISOPROPYL-P-TOLUIDINE
• CAS No.: 10436-75-6
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• Hs Code.: 2921430090
• Mol file: 10436-75-6.mol

Synonyms:N-ISOPROPYL-P-TOLUIDINE

Chemical Property of N-ISOPROPYL-P-TOLUIDINE

Chemical Property:

• Melting Point: 1.08°C (estimate)
• Refractive Index: 1.5332
• Boiling Point: 240.76°C (estimate)
• PSA: 12.03000
• Density: 0.9226
• LogP: 2.88830

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methyl-N-(propan-2-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ISOPROPYL-P-TOLUIDINE

There total 14 articles about N-ISOPROPYL-P-TOLUIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-toluidine (106-49-0,12221-03-3) + diisopropylamine (108-18-9) → N-isopropyl-p-toluidine (10436-75-6)

Guidance literature:

With [(C₅Me₄)(CH₂)₃(C₅Me₄)(IrI₂)₂]_m; In 5,5-dimethyl-1,3-cyclohexadiene; at 155 ℃; for 10h; Schlenk technique; Reflux;

DOI:10.1021/om4001742

Reference yield: 97.0%

p-toluidine (106-49-0,12221-03-3) + acetone (67-64-1) → N-isopropyl-p-toluidine (10436-75-6)

Guidance literature:

With iridium bromide; formic acid; zinc; In water; at 30 ℃; for 20h;

DOI:10.1016/j.tetlet.2009.11.107

Reference yield: 94.2%

p-toluidine (106-49-0,12221-03-3) + isopropyl bromide (75-26-3) → N-isopropyl-p-toluidine (10436-75-6)

Guidance literature:

With sodium hydrogencarbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; for 2h; Heating; 3 equivalents of i-PrBr;

DOI:10.1016/S0040-4039(01)91065-2

upstream raw materials:

2,5-dimethyl-2,5-di-p-toluidino-[1,4]dithiane

2-iodo-propane

p-toluidine

isopropyl alcohol

Downstream raw materials:

N--4-methylaniline

[iPrNH₂(4-MeC₆H₁₀)][HB(C₆F₅)3]

p-toluidine

benzal-p-toluidine

Refernces

• 1、 Tappen, Jens,Rodstein, Ilja,McGuire, Katie,Gro?johann, Angela,L?ffler, Julian,Scherpf, Thorsten,Gessner, Viktoria H.. "Palladium Complexes Based on Ylide-Functionalized Phosphines (YPhos): Broadly Applicable High-Performance Precatalysts for the Amination of Aryl Halides at Room Temperature". supporting information. p. 4281 - 4288. Retrieved 2020/03/13.
• 2、 Castillo, Juan-Carlos,Orrego-Hernández, Jessica,Portilla, Jaime. "Cs2CO3-Promoted Direct N-Alkylation: Highly Chemoselective Synthesis of N-Alkylated Benzylamines and Anilines". . p. 3824 - 3835. Retrieved 2016/08/20.