dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid

Base Information

• Chemical Name: dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid
• CAS No.: 144707-04-0
• Molecular Formula: C₁₇H₂₄O₆
• Molecular Weight: 324.374
• Mol file: 144707-04-0.mol

Synonyms:dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid

Chemical Property of dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid

There total 4 articles about dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.7%

1-chloromethyl-2,5-dimethoxy-3,4,6-trimethyl-benzene (54757-17-4) + sodium methylate (124-41-4) → 1,4-dimethoxy-2-methoxymethyl-3,5,6-trimethylbenzene (144707-05-1) + dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid (144707-04-0)

Guidance literature:

With malonic acid dimethyl ester; In methanol; for 3h; Heating;

DOI:10.1007/BF00473932

Reference yield:

Trimethylhydroquinone (700-13-0) → dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid (144707-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 52.5 percent / K₂CO₃ / acetone / 48 h / Heating

2: 96.3 percent / hydrogen chloride / dioxane; H₂O / 5 h / 20 °C

3: 1.) sodium methoxide / 1.) methanol, 20 min., reflux, 2.) methanol, 3 h, reflux

With hydrogenchloride; sodium methylate; potassium carbonate; In 1,4-dioxane; water; acetone;

DOI:10.1007/BF00473932

Reference yield:

1,4-dimethoxy-2,3,5-trimethyl-benzene (4537-09-1) → dimethyl esther of 2-(2,5-dimethoxy-3,4,6-trimethylphenylmethyl)malonic acid (144707-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.3 percent / hydrogen chloride / dioxane; H₂O / 5 h / 20 °C

2: 1.) sodium methoxide / 1.) methanol, 20 min., reflux, 2.) methanol, 3 h, reflux

With hydrogenchloride; sodium methylate; In 1,4-dioxane; water;

DOI:10.1007/BF00473932

upstream raw materials:

1-chloromethyl-2,5-dimethoxy-3,4,6-trimethyl-benzene

sodium methylate

malonic acid dimethyl ester

Trimethylhydroquinone

Downstream raw materials:

1,4-dimethoxy-2-(3-hydroxypropyl)-3,5,6-trimethylbenzene

methyl esther of 3-(2,5-dimethoxy-3,4,6-trimethylphenyl)propionic acid

2-(3-hydroxypropyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione