N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester

Base Information

Chemical Name:N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester
CAS No.:1352655-89-0
Molecular Formula:C₂₂H₂₃ClN₂O₅
Molecular Weight:430.888
Hs Code.:

Synonyms:N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester

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Chemical Property of N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester

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Technology Process of N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester

There total 1 articles about N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 79-04-9
chloroacetyl chloride

: 329191-57-3
(2S,4S)-N^α-Cbz-4-aminoproline benzyl ester

: 1352655-89-0
N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃; for 3h;
DOI:10.1002/adsc.201100595

Reference yield: 65.0%

: 616-47-7
1-methyl-1H-imidazole

: 1352655-89-0
N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester

: 1352655-90-3
C₂₆H₂₉N₄O₅⁽¹⁺⁾*Cl^(1-)

Guidance literature:: In acetonitrile; at 50 ℃; for 16h;
DOI:10.1002/adsc.201100595

Reference yield:

: 1352655-89-0
N-benzyloxycarbonyl-(2S,4S)-4-(2-chloroacetamido)-proline benzyl ester

: BF₄^(1-)*C₂₆H₂₉N₄O₅⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 16 h / 50 °C

2: sodium tetrafluoroborate / dichloromethane / 12 h / 25 °C

With sodium tetrafluoroborate; In dichloromethane; acetonitrile;
DOI:10.1002/adsc.201100595