(E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

Base Information

Chemical Name:(E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate
CAS No.:168162-46-7
Molecular Formula:C₃₃H₂₆F₂N₂O₄
Molecular Weight:552.577
Hs Code.:

Synonyms:(E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

Chemical Property:

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Technology Process of (E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

There total 10 articles about (E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 168164-00-9
(E)-methyl [1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzo-azepine-5-ylidene]acetate

: 168162-46-7
(E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1248/cpb.48.1644

Reference yield:

: 79-37-8
oxalyl dichloride

: 168164-00-9
(E)-methyl [1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzo-azepine-5-ylidene]acetate

: 947-84-2
2-Biphenylcarboxylic acid

: 168162-46-7
(E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

Guidance literature:

Reference yield:

: 24310-36-9
1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 168162-46-7
(E)-methyl {4,4-difluoro-1-[4-(2-phenylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzoazepine-5-ylidene}acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 78 percent / N-fluoro-benzenesulfonimide / tetrahydrofuran / 1 h / 0 °C

2.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: N-fluoropyridinium trifluoromethanesulfonate / CH₂Cl₂ / 2 h / Heating

4.1: H₂SO₄; AcOH / 14 h / 60 °C

5.1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

6.1: 83 percent / SnCl₂ / ethyl acetate / 5 h / Heating

7.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

7.2: 24 percent / tetrahydrofuran / 10 h / -78 - 0 °C

8.1: pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; sulfuric acid; sodium hydride; N-fluoropyridinium triflate; acetic acid; triethylamine; tin(ll) chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.48.1644