N-TRIFLUOROACETYL-L-CYSTEINE METHYL ESTER

Base Information

• Chemical Name: N-TRIFLUOROACETYL-L-CYSTEINE METHYL ESTER
• CAS No.: 1577-62-4
• Molecular Formula: C6H8 F3 N O3 S
• Molecular Weight: 231.196
• Hs Code.: 2930909090
• Mol file: 1577-62-4.mol

Synonyms:Cysteine,N-(trifluoroacetyl)-, methyl ester (7CI); Cysteine, N-(trifluoroacetyl)-,methyl ester, L- (8CI); N-(Trifluoroacetyl)cysteine methyl ester;N-Trifluoroacetyl-L-cysteine methyl ester

Chemical Property of N-TRIFLUOROACETYL-L-CYSTEINE METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00598mmHg at 25°C
• Refractive Index: 1.432
• Boiling Point: 272.7°Cat760mmHg
• PKA: 8.81±0.10(Predicted)
• Flash Point: 118.7°C
• PSA: 94.20000
• Density: 1.377g/cm³
• LogP: 0.52720
• Storage Temp.: Store in freezer

Purity/Quality:

97% ^*data from raw suppliers

N-Trifluoroacetyl-L-cysteine methyl ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-TRIFLUOROACETYL-L-CYSTEINE METHYL ESTER

There total 2 articles about N-TRIFLUOROACETYL-L-CYSTEINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + cycloforskamide (1447695-69-3) + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetyl-(S)-valine methyl ester (1463-21-4) + (2S,3S)-methyl 3-methyl-2-(2,2,2-trifluoroacetamido)pentanoate (1808-42-0,1577-58-8,23635-22-5,29588-17-8,81131-21-7,81131-22-8,81131-23-9) + C9H14F3NO3 (81131-21-7) + N-trifluoroacetyl-L-cysteine methyl ester (1577-62-4) + N-Trifluormethyl-threonin-methylester (88494-53-5) + (R)-1-(2,2,2-Trifluoro-acetyl)-pyrrolidine-2-carboxylic acid methyl ester (344-25-2)

Guidance literature:

cycloforskamide; With hydrogenchloride; water; at 110 ℃; for 24h;

methanol; With hydrogenchloride; at 100 ℃; for 0.5h;

trifluoroacetic anhydride; In dichloromethane; at 100 ℃; for 0.0833333h;

DOI:10.1021/np400404r

Reference yield:

L-cysteine methyl ester hydrochloride (18598-63-5) + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetyl-L-cysteine methyl ester (1577-62-4)

Guidance literature:

In dichloromethane; at 100 ℃; for 0.0833333h;

DOI:10.1021/np400404r

Reference yield: 47.0%

N-trifluoroacetyl-L-cysteine methyl ester (1577-62-4) + (5S,6S,7Z)-methyl 5,6-oxido-9-(4-heptylphenyl)-7-nonenoate (104948-09-6) → (5S,6R,7Z)-6--5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester (104948-16-5)

Guidance literature:

With triethylamine; In methanol;

DOI:10.1021/jm00162a010

upstream raw materials:

methanol

cycloforskamide

trifluoroacetic anhydride

L-cysteine methyl ester hydrochloride

Downstream raw materials:

S-(2,2,2-Trifluor-1-benzyloxycarbonylamino-ethyl)-N-trifluoracetyl-L-cysteinmethylester

(5S,6R,7Z)-6--5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester

(Z)-(5S,6R)-9-(2-Heptyl-phenyl)-5-hydroxy-6-[(R)-2-methoxycarbonyl-2-(2,2,2-trifluoro-acetylamino)-ethylsulfanyl]-non-7-enoic acid methyl ester