N-TFA-DL-THREONINE METHYL ESTER

Base Information

• Chemical Name: N-TFA-DL-THREONINE METHYL ESTER
• CAS No.: 88494-53-5
• Molecular Formula: C₇H₁₀F₃NO₄
• Molecular Weight: 229.156
• Hs Code.: 2924199090
• Mol file: 88494-53-5.mol

Synonyms:DL-Threonine,N-(trifluoroacetyl)-, methyl ester

Chemical Property of N-TFA-DL-THREONINE METHYL ESTER

Chemical Property:

• PSA: 79.12000
• LogP: 0.42760
• Storage Temp.: 2-8°C

Purity/Quality:

99%+ ^*data from raw suppliers

N-TFA-DL-THREONINE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-TFA-DL-THREONINE METHYL ESTER

There total 7 articles about N-TFA-DL-THREONINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl trifluoroacetate, (383-63-1) + L-threonine methyl ester hydrochloride (39994-75-7) → N-Trifluormethyl-threonin-methylester (88494-53-5)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 1.5h; Cooling with ice;

Reference yield:

methanol (67-56-1) + cycloforskamide (1447695-69-3) + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetyl-(S)-valine methyl ester (1463-21-4) + (2S,3S)-methyl 3-methyl-2-(2,2,2-trifluoroacetamido)pentanoate (1808-42-0,1577-58-8,23635-22-5,29588-17-8,81131-21-7,81131-22-8,81131-23-9) + C9H14F3NO3 (81131-21-7) + N-trifluoroacetyl-L-cysteine methyl ester (1577-62-4) + N-Trifluormethyl-threonin-methylester (88494-53-5) + (R)-1-(2,2,2-Trifluoro-acetyl)-pyrrolidine-2-carboxylic acid methyl ester (344-25-2)

Guidance literature:

cycloforskamide; With hydrogenchloride; water; at 110 ℃; for 24h;

methanol; With hydrogenchloride; at 100 ℃; for 0.5h;

trifluoroacetic anhydride; In dichloromethane; at 100 ℃; for 0.0833333h;

DOI:10.1021/np400404r

Reference yield:

methanol (67-56-1) + nyuzenamide B + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetyl-(S)-valine methyl ester (1463-21-4) + N-trifluoroacetyl-(2S)-proline methyl ester (715-58-2) + N-TFA-D-Leu-OMe (81083-98-9) + N-Trifluormethyl-threonin-methylester (88494-53-5) + (R)-N-trifluoroacetylaspartic acid-1-methyl ester (945984-91-8)

Guidance literature:

nyuzenamide B; With hydrogenchloride; In water; at 105 ℃; Inert atmosphere;

methanol; With hydrogenchloride; In water; at 100 ℃; for 0.5h; Inert atmosphere;

trifluoroacetic anhydride; In dichloromethane; at 100 ℃; for 0.0833333h;

DOI:10.1021/acs.orglett.1c00210

upstream raw materials:

methanol

L-threonine

trifluoroacetic acid-methyl ester

L-threonine methyl ester hydrochloride