4,4,4-TRIFLUORO-3-HYDROXY-1-PHENYLBUTANE-1-ONE

Base Information

• Chemical Name: 4,4,4-TRIFLUORO-3-HYDROXY-1-PHENYLBUTANE-1-ONE
• CAS No.: 1524-15-8
• Molecular Formula: C10H9 F3 O2
• Molecular Weight: 218.175
• Hs Code.: 2914700090
• Mol file: 1524-15-8.mol

Synonyms:Butyrophenone,4,4,4-trifluoro-3-hydroxy- (7CI,8CI);4,4,4-Trifluoro-3-hydroxy-1-phenyl-1-butanone

Chemical Property of 4,4,4-TRIFLUORO-3-HYDROXY-1-PHENYLBUTANE-1-ONE

Chemical Property:

• PSA: 37.30000
• LogP: 2.18260

Purity/Quality:

98%min ^*data from raw suppliers

4,4,4-Trifluoro-3-hydroxy-1-phenylbutan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4-TRIFLUORO-3-HYDROXY-1-PHENYLBUTANE-1-ONE

There total 27 articles about 4,4,4-TRIFLUORO-3-HYDROXY-1-PHENYLBUTANE-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,2,2-trifluoro-1,1-ethanediol (421-53-4) + N-(1-phenylethylidene)cyclohexylamine (67888-71-5,1562-62-5) → 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one (1524-15-8)

Guidance literature:

In various solvent(s); Heating;

DOI:10.1021/jo026697j

Reference yield: 91.0%

N-(1-phenylethylidene)cyclohexylamine (67888-71-5,1562-62-5) + ethyl trifluoroacetaldehyde hemiacetal (433-27-2) → 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one (1524-15-8)

Guidance literature:

N-(1-phenylethylidene)cyclohexylamine; ethyl trifluoroacetaldehyde hemiacetal; In hexane; for 1h; Heating;

With silica gel; In hexane; ethyl acetate;

DOI:10.1055/s-1999-2870

Reference yield: 89.0%

N-(1-phenylethylidene)hexan-1-amine (66521-29-7) + ethyl trifluoroacetaldehyde hemiacetal (433-27-2) → 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one (1524-15-8)

Guidance literature:

N-(1-phenylethylidene)hexan-1-amine; ethyl trifluoroacetaldehyde hemiacetal; In hexane; for 1h; Heating;

With silica gel; In hexane; ethyl acetate;

DOI:10.1055/s-1999-2870

upstream raw materials:

2,2,2-Trifluoroacetaldehyde

1,3-diphenylpropanedione

1-phenyl-1-(N-phenylamino)-4,4,4-trifluoro-1-buten-3-one

acetophenone

Downstream raw materials:

1-phenyl-4,4,4-trifluoro-1,2-butanediol

1-Phenyl-4,4,4-trifluoro-2,3-epoxy-1-butanone

2-Chlor-1,1,1-trifluor-4-phenyl-4-butanon

(E)-4,4,4-trifluoro-1-phenyl-2-buten-1-one