p-Nitrophenyl 2-chloronicotinate

Base Information

• Chemical Name: p-Nitrophenyl 2-chloronicotinate
• CAS No.: 76980-32-0
• Molecular Formula: C₁₂H₇ClN₂O₄
• Molecular Weight: 278.652
• Mol file: 76980-32-0.mol

Synonyms:p-Nitrophenyl 2-chloronicotinate

Chemical Property of p-Nitrophenyl 2-chloronicotinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of p-Nitrophenyl 2-chloronicotinate

There total 1 articles about p-Nitrophenyl 2-chloronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-chloronicotinic acid (2942-59-8) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → p-Nitrophenyl 2-chloronicotinate (76980-32-0)

Guidance literature:

With dicyclohexyldicarboimide; In pyridine; at 20 ℃; for 5h;

DOI:10.1007/BF01156373

Reference yield: 80.0%

p-Nitrophenyl 2-chloronicotinate (76980-32-0) + glycine (56-40-6,18875-39-3,25718-94-9) → [(2-Chloro-pyridine-3-carbonyl)-amino]-acetic acid (76980-21-7)

Guidance literature:

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

DOI:10.1007/BF01156373

Reference yield: 76.0%

p-Nitrophenyl 2-chloronicotinate (76980-32-0) + 3-amino propanoic acid (107-95-9) → 3-[(2-Chloro-pyridine-3-carbonyl)-amino]-propionic acid (76980-22-8)

Guidance literature:

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

DOI:10.1007/BF01156373

upstream raw materials:

2-chloronicotinic acid

4-nitro-phenol

Downstream raw materials:

(S)-2-[(2-Chloro-pyridine-3-carbonyl)-amino]-pentanedioic acid

2-[(2-Chloro-pyridine-3-carbonyl)-amino]-3-phenyl-propionic acid

[(2-Chloro-pyridine-3-carbonyl)-amino]-acetic acid

3-[(2-Chloro-pyridine-3-carbonyl)-amino]-propionic acid

Refernces