3-(2,5-dioxopyrrolidin-1-yl)propanoic acid

Base Information

• Chemical Name: 3-(2,5-dioxopyrrolidin-1-yl)propanoic acid
• CAS No.: 5724-76-5
• Molecular Formula: C7H9NO4
• Molecular Weight: 171.1507
• Hs Code.: 2925190090
• Mol file: 5724-76-5.mol

Synonyms:1-Pyrrolidinepropionicacid, 2,5-dioxo- (6CI,7CI,8CI);2,5-Dioxopyrrolidinepropanoic acid;3-(2,5-Dioxopyrrolidin-1-yl)propanoic acid;3-Succinimidopropionic acid;NSC58206;b-(N-Succinimido)propionic acid;

Chemical Property of 3-(2,5-dioxopyrrolidin-1-yl)propanoic acid

Chemical Property:

• Vapor Pressure: 1.6E-08mmHg at 25°C
• Melting Point: 131-132 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.534
• Boiling Point: 427.9 °C at 760 mmHg
• PKA: 4.17±0.10(Predicted)
• Flash Point: 212.6 °C
• PSA: 74.68000
• Density: 1.408 g/cm³
• LogP: -0.45200
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dioxo-1-pyrrolidinepropanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-(2,5-dioxopyrrolidin-1-yl)propanoic acid

There total 4 articles about 3-(2,5-dioxopyrrolidin-1-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

succinic acid anhydride (108-30-5) + 3-amino propanoic acid (107-95-9) → 3-succinimidopropionic acid (5724-76-5)

Guidance literature:

With acetic acid; for 10h; Heating;

Reference yield:

3-(2,5-dioxo-pyrrolidin-1-yl)propionaldehyde (5615-85-0) → 3-succinimidopropionic acid (5724-76-5)

Guidance literature:

With sodium hydroxide; potassium permanganate; water;

DOI:10.1021/ja01172a031

Reference yield:

Succinimide (123-56-8,89963-74-6) + β-Propiolactone (57-57-8) → 3-succinimidopropionic acid (5724-76-5)

Guidance literature:

With sodium hydroxide; water;

DOI:10.1021/ja01125a054

upstream raw materials:

succinic acid anhydride

3-amino propanoic acid

3-(2,5-dioxo-pyrrolidin-1-yl)propionaldehyde

Succinimide

Downstream raw materials:

β,2,5-Trioxo-α-(triphenylphosphoranyliden)pyrrolidin-1-pentansaeure-ethylester

β,2,5-Trioxo-α-(triphenylphosphoranyliden)pyrrolidin-1-pentansaeure-1,1-dimethylethylester

1-<3-Oxo-4-(triphenylphosphoranyliden)butyl>-2,5-pyrrolidindion Hydroiodid

1-<3-Oxo-4-(triphenylphosphoranyliden)butyl>-2,5-pyrrolidindion