2-METHYL-2-(4-NITROPHENYL)-2-PROPANOL

Base Information

• Chemical Name: 2-METHYL-2-(4-NITROPHENYL)-2-PROPANOL
• CAS No.: 22357-57-9
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Mol file: 22357-57-9.mol

Synonyms:2-(4-nitrophenyl)propan-2-ol

Chemical Property of 2-METHYL-2-(4-NITROPHENYL)-2-PROPANOL

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(4-nitrophenyl)propan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-2-(4-NITROPHENYL)-2-PROPANOL

There total 27 articles about 2-METHYL-2-(4-NITROPHENYL)-2-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-nitrocumene (1817-47-6) → 2-(4-nitrophenyl)propan-2-ol (22357-57-9)

Guidance literature:

4-nitrocumene; With cis-RuCl₂(4,4'-di-tert-butyl-2,2'-bipyridine)2; acetic acid; In water; for 0.0333333h; Darkness;

With periodic acid; In water; for 4h; chemoselective reaction; Darkness;

DOI:10.1021/jacs.7b05469

Reference yield: 80.0%

methyltrichlorotitanium (2747-38-8) + (4-nitrophenyl)ethanone (100-19-6) → 2-(4-nitrophenyl)propan-2-ol (22357-57-9)

Guidance literature:

In diethyl ether; at 0 ℃; for 3h;

DOI:10.1016/S0040-4020(01)90582-4

Reference yield: 80.0%

methylmagnesium chloride (676-58-4) + (4-nitrophenyl)ethanone (100-19-6) → 2-(4-nitrophenyl)propan-2-ol (22357-57-9)

Guidance literature:

With titanium tetrachloride; In diethyl ether;

DOI:10.1016/S0040-4020(01)90582-4

upstream raw materials:

4-nitrocumene

2-(4-nitrophenyl)-2-propyl hydroperoxide

4-nitrocumyl chloride

Isopropylbenzene

Downstream raw materials:

p-Nitrocumyl p-toluenesulfinate

4-nitrocumyl chloride

2,4,6-tribromoaniline

acetone

Refernces

• 1、 Doiuchi, Daiki,Uchida, Tatsuya. "Catalytic Highly Regioselective C-H Oxygenation Using Water as the Oxygen Source: Preparation of 17O/18O-Isotope-Labeled Compounds". supporting information. p. 7301 - 7305. Retrieved 2021/10/01.
• 2、 Robinson, Sophia G.,MacK, James B. C.,Alektiar, Sara N.,Du Bois,Sigman, Matthew S.. "Electrochemical Ruthenium-Catalyzed C-H Hydroxylation of Amine Derivatives in Aqueous Acid". supporting information. p. 7060 - 7063. Retrieved 2020/06/05.