2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE

Base Information

• Chemical Name: 2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE
• CAS No.: 1005-28-3
• Molecular Formula: C₆H₈N₂OS
• Molecular Weight: 156.208
• Hs Code.: 2934100090
• Mol file: 1005-28-3.mol

Synonyms:2-(Dimethylamino)thiazole-5-carboxaldehyde

Chemical Property of 2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0182mmHg at 25°C
• Refractive Index: 1.638
• Boiling Point: 253.5°C at 760 mmHg
• Flash Point: 107.1°C
• PSA: 61.44000
• Density: 1.282g/cm³
• LogP: 1.02160

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Dimethylamino)-1,3-thiazole-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE

There total 7 articles about 2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chloro-1,3-thiazole-5-carbaldehyde (95453-58-0) + dimethyl amine (124-40-3) → 2-(dimethylamino)thiazole-5-carbaldehyde (1005-28-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; for 20h;

Reference yield: 81.0%

2-bromo-1,3-thiazole-5-carbaldehyde (464192-28-7) + dimethyl amine (124-40-3) → 2-(dimethylamino)thiazole-5-carbaldehyde (1005-28-3)

Guidance literature:

In water; for 4h; Reflux;

Reference yield: 43.0%

2-chlorothiazole (3034-52-4) → 2-(dimethylamino)thiazole-5-carbaldehyde (1005-28-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether;

upstream raw materials:

2-chlorothiazole

N,N-dimethyl-formamide

2-dimethylamino-1,3-thiazole

2-chloro-1,3-thiazole-5-carbaldehyde

Refernces

• 1、 -. "SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE". Page/Page column 734. . Retrieved 2016/04/10.
• 2、 -. "Dehydroamino acids". . . Retrieved 2008/06/13.