trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene
• CAS No.: 89357-92-6
• Molecular Formula: C₁₇H₁₈OSe
• Molecular Weight: 317.289
• Mol file: 89357-92-6.mol

Synonyms:trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene

Chemical Property of trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene

There total 5 articles about trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + Phenylselenyl chloride (5707-04-0) + 1,4-dihydronaphthalene (612-17-9) → trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene (89357-92-6)

Guidance literature:

With triethylamine; at 25 ℃; for 20h;

DOI:10.1039/c39830001501

Reference yield: 76.0%

trans-2-hydroxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene (98329-55-6) + methyl iodide (74-88-4) → trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene (89357-92-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 1h; -78 deg C to RT;

Reference yield:

2,3-epoxy-1,2,3,4-tetrahydronaphthalene (2461-35-0) → trans-2-methoxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene (89357-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol / 20 - 25 °C

2: 76 percent / NaH / tetrahydrofuran / 1 h / -78 deg C to RT

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; ethanol;

upstream raw materials:

methanol

Phenylselenyl chloride

1,4-dihydronaphthalene

trans-2-hydroxy-3-phenylseleno-1,2,3,4-tetrahydronaphthalene

Downstream raw materials:

(E)-3-phenylpropenal

1-Phenyl-2-propen-1-ol

1-phenylallyl methyl ether

(E)-(3-methoxyprop-1-en-1-yl)benzene