Technology Process of 4-ethyl-3-(2-hydroxy-ethyl)-benzoic acid methyl ester
There total 8 articles about 4-ethyl-3-(2-hydroxy-ethyl)-benzoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
camphor-10-sulfonic acid;
In
methanol; dichloromethane;
at 20 ℃;
for 16h;
DOI:10.1021/jm990448e
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: O3 / methanol / 0.08 h / -78 °C
1.2: NaBH4 / methanol / 14 h / -78 - 20 °C
2.1: 71 percent / imidazole / dimethylformamide / 14 h / 20 °C
3.1: Et3N / tetrahydrofuran / -78 - 20 °C
4.1: (PPh3)2PdCl2; PPh3; LiCl / dimethylformamide / 14 h / 90 °C
5.1: H2 / 10percent Pd/C / ethyl acetate / 1 h / 1551.49 Torr
6.1: camphorsulfonic acid / methanol; CH2Cl2 / 16 h / 20 °C
With
1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; camphor-10-sulfonic acid; hydrogen; ozone; triethylamine; triphenylphosphine; lithium chloride;
10percent Pd/C;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
1.1: Ozonolysis / 1.2: Reduction / 2.1: Silylation / 3.1: Triflation / 4.1: Vinylation / 5.1: Catalytic hydrogenation / 6.1: Desilylation;
DOI:10.1021/jm990448e
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: BCl3 / chlorobenzene / 8 h / 20 °C
2.1: O3 / methanol / 0.08 h / -78 °C
2.2: NaBH4 / methanol / 14 h / -78 - 20 °C
3.1: 71 percent / imidazole / dimethylformamide / 14 h / 20 °C
4.1: Et3N / tetrahydrofuran / -78 - 20 °C
5.1: (PPh3)2PdCl2; PPh3; LiCl / dimethylformamide / 14 h / 90 °C
6.1: H2 / 10percent Pd/C / ethyl acetate / 1 h / 1551.49 Torr
7.1: camphorsulfonic acid / methanol; CH2Cl2 / 16 h / 20 °C
With
1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; camphor-10-sulfonic acid; hydrogen; boron trichloride; ozone; triethylamine; triphenylphosphine; lithium chloride;
10percent Pd/C;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene;
1.1: Rearrangement / 2.1: Ozonolysis / 2.2: Reduction / 3.1: Silylation / 4.1: Triflation / 5.1: Vinylation / 6.1: Catalytic hydrogenation / 7.1: Desilylation;
DOI:10.1021/jm990448e
![3-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-4-ethyl-benzoic acid methyl ester](/Databaselist/images/loading.webp)
