(4S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

Base Information

Chemical Name:(4S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
CAS No.:22916-26-3
Molecular Formula:C6H11 N O2 S
Molecular Weight:161.22
Hs Code.:2934999090
European Community (EC) Number:630-754-1
DSSTox Substance ID:DTXSID30384704
Nikkaji Number:J292.627J
Wikidata:Q76149074
Mol file:22916-26-3.mol

Synonyms:22916-26-3;(S)-4-CARBOXY-5,5-DIMETHYLTHIAZOLIDINE;(4S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid;(S)-5,5-Dimethylthiazolidine-4-carboxylic acid;4-Thiazolidinecarboxylic acid, 5,5-dimethyl-, (4S)-;SCHEMBL951739;DTXSID30384704;PMQQFSDIECYOQV-BYPYZUCNSA-N;MFCD00037512;AKOS025310756;AS-68788;CS-0204965;(S)-5,5-Dimethylthiazolidine-4-carboxylicacid;H-,-Dimethyl-D-Cys-OH;H--Mercapto-D-Val-OH;(4S)-5,5-Dimethyl-4-thiazolidinecarboxylic acid;A911123

Suppliers and Price of (4S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-4-Carboxy-5,5-dimethylthiazolidine
50mg
$ 55.00

Crysdot
(S)-5,5-Dimethylthiazolidine-4-carboxylicacid 95+%
10g
$ 438.00

Crysdot
(S)-5,5-Dimethylthiazolidine-4-carboxylicacid 95+%
25g
$ 818.00

Chem-Impex
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylicacid,99%(HPLC) 99%(HPLC)
25G
$ 973.28

Chem-Impex
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylicacid,99%(HPLC) 99%(HPLC)
5G
$ 324.80

Chem-Impex
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylicacid,99%(HPLC) 99%(HPLC)
1G
$ 81.20

Chemenu
(S)-5,5-Dimethylthiazolidine-4-carboxylicacid 95%
25g
$ 772.00

Chemenu
(S)-5,5-Dimethylthiazolidine-4-carboxylicacid 95%
10g
$ 413.00

Biosynth Carbosynth
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
5 g
$ 390.30

Biosynth Carbosynth
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
10 g
$ 624.50

Total 7 raw suppliers

Chemical Property of (4S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

Chemical Property:

Melting Point:200-203 °C(Solv: methanol (67-56-1))
Boiling Point:317.3±37.0 °C(Predicted)
PKA:2.11±0.40(Predicted)
PSA：74.63000
Density:1.195±0.06 g/cm3(Predicted)
LogP:0.84090
XLogP3:-1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:161.05104977
Heavy Atom Count:10
Complexity:158

Purity/Quality:

97% ^*data from raw suppliers

(S)-4-Carboxy-5,5-dimethylthiazolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(NCS1)C(=O)O)C
Isomeric SMILES:CC1([C@@H](NCS1)C(=O)O)C
Uses (S)-4-Carboxy-5,5-dimethylthiazolidine is a Proline-Catalyst for Mannich reactions.

Technology Process of (4S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

There total 3 articles about (4S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 52-67-5
3,3-dimethyl-D-cysteine

: 22916-26-3
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

Guidance literature:: In ethanol; water; at 20 ℃; for 18h;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 52-66-4
DL-Penicillamin

: 72778-00-8
(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

: 22916-26-3
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 60 ℃; for 2h;
DOI:10.1002/ardp.19863190515

Reference yield:

: 85929-61-9
methyl (+/-)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate

: 70491-75-7
methyl (S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate

: 72778-00-8
(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

: 22916-26-3
(S)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

: methyl (R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate

Guidance literature:: methyl (+/-)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate; With Klebsiella oxytoca hydrolase; In water; at 60 ℃; for 26h;

With sodium hydroxide; pH=11.5; Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(02)00257-4