9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine

Base Information

Chemical Name:9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine
CAS No.:705965-06-6
Molecular Formula:C₂₄H₂₅ClN₈O₂
Molecular Weight:492.968
Hs Code.:

Synonyms:9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine

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Chemical Property of 9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine

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Technology Process of 9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine

There total 8 articles about 9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 10310-21-1
2-Amino-6-chloropurin

: 705965-05-5
methanesulfonic acid 3-azido-4-benzyloxy-3-benzyloxymethyl-butanyl ester

: 7-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-7H-purin-2-ylamine

: 705965-06-6
9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1039/b401100g

Reference yield:

: 27441-79-8
2-methylenepropane-1,3-bisbenzyl ether

: 705965-06-6
9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / O₃ / methanol / 2 h / -78 °C

2: 86 percent / NaH / tetrahydrofuran / 1 h / 20 °C

3: 89 percent / NaN₃; aq. AcOH / 168 h / 80 °C

4: DIBALH / CH₂Cl₂; toluene / 2 h / -78 °C

5: 270 mg / NaBH₄ / ethanol / 0.25 h / -20 °C

6: 100 percent / pyridine / 0.25 h / 0 °C

7: 79 percent / K₂CO₃ / dimethylformamide / 60 °C

With pyridine; sodium tetrahydroborate; sodium azide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ozone; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 2: Horner-Emmons olefination;
DOI:10.1039/b401100g

Reference yield:

: 77356-14-0
1,3-dibenzyloxy-2-propanone

: 705965-06-6
9-(3-azido-4-benzyloxy-3-benzyloxymethyl-butyl)-6-chloro-9H-purin-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / NaH / tetrahydrofuran / 1 h / 20 °C

2: 89 percent / NaN₃; aq. AcOH / 168 h / 80 °C

3: DIBALH / CH₂Cl₂; toluene / 2 h / -78 °C

4: 270 mg / NaBH₄ / ethanol / 0.25 h / -20 °C

5: 100 percent / pyridine / 0.25 h / 0 °C

6: 79 percent / K₂CO₃ / dimethylformamide / 60 °C

With pyridine; sodium tetrahydroborate; sodium azide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Horner-Emmons olefination;
DOI:10.1039/b401100g