tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

Base Information

Chemical Name:tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate
CAS No.:911313-03-6
Molecular Formula:C₂₆H₃₄ClN₃O₄
Molecular Weight:488.027
Hs Code.:

Synonyms:tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

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Chemical Property of tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

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Technology Process of tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

There total 3 articles about tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911312-98-6
2-chloro-N-{2-[((R)-2-hydroxy-1-methylethylamino)methyl]-phenyl}-4-pyrrolidin-1-ylbenzamide

: 24424-99-5
di-tert-butyl dicarbonate

: 911313-03-6
tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 21h;

Reference yield:

: 192513-60-3
2-chloro-(4-pyrrolidin-1-yl) benzoic acid

: 911313-03-6
tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

2: triethylamine / dichloromethane / 66 h / 0 - 20 °C

3: potassium carbonate / ethanol / 1 h / Heating / reflux

4: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

5: dichloromethane / 21 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; ethanol; potassium carbonate; triethylamine; 1-methyl-pyrrolidin-2-one; In ethanol; dichloromethane;

Reference yield:

: 911312-93-1
2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

: 911313-03-6
tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 66 h / 0 - 20 °C

2: potassium carbonate / ethanol / 1 h / Heating / reflux

3: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

4: dichloromethane / 21 h / 20 °C

With sodium tetrahydroborate; ethanol; potassium carbonate; triethylamine; In ethanol; dichloromethane;