3,5-Dichloro-2,4,6-trimethoxypyridine

Base Information

• Chemical Name: 3,5-Dichloro-2,4,6-trimethoxypyridine
• CAS No.: 2412-97-7
• Molecular Formula: C₈H₉Cl₂NO₃
• Molecular Weight: 238.07
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70485209
• Nikkaji Number: J950.245I
• Wikidata: Q82324193
• Mol file: 2412-97-7.mol

Synonyms:3,5-DICHLORO-2,4,6-TRIMETHOXYPYRIDINE;2412-97-7;2,4,6-Trimethoxy-3,5-dichloropyridine;DTXSID70485209;3,5-Dichloro-2,4,6-trimethoxy-pyridine;FT-0703762;A26080

Chemical Property of 3,5-Dichloro-2,4,6-trimethoxypyridine

Chemical Property:

• PSA: 40.58000
• LogP: 2.41420
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 236.9959485
• Heavy Atom Count: 14
• Complexity: 168

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dichloro-2,4,6-trimethoxypyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=NC(=C1Cl)OC)OC)Cl

Technology Process of 3,5-Dichloro-2,4,6-trimethoxypyridine

There total 9 articles about 3,5-Dichloro-2,4,6-trimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

sodium methylate (124-41-4) + (3,5-dichloropyridine-2,4,6-triyl)-1,1',1''-tris[4-(dimethylamino)pyridinium] trichloride → 3,5-dichloro-2,4,6-trimethoxypyridine (2412-97-7)

Guidance literature:

In methanol; for 6h; Heating;

DOI:10.1055/s-2005-861827

Reference yield: 99.0%

methanol (67-56-1) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) → 3,5-dichloro-2,4,6-trimethoxypyridine (2412-97-7)

Guidance literature:

With sodium methylate; for 48h; Heating;

DOI:10.1016/j.jfluchem.2005.01.018

Reference yield: 20.0%

methanol (67-56-1) + 2,3,4,5,6-pentachloropyridine (2176-62-7) → 2-Hydroxy-4-methoxy-3,5,6-trichloropyridine (19946-32-8) + 3,5,6-trichloro-2,4-dimethoxypyridine (10469-13-3) + 3,5-dichloro-2,4,6-trimethoxypyridine (2412-97-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; 1.) r.t., 30 min, 2.) r.t., 24 h;

DOI:10.1016/S0022-1139(97)00094-8

upstream raw materials:

2,4,6-trimethoxypyridine

methanol

2,3,4,5,6-pentachloropyridine

sodium methylate

Downstream raw materials:

2,4,6-trimethoxypyridine