7-METHOXY-1,4-BENZOTHIAZIN-3-ONE

Base Information

• Chemical Name: 7-METHOXY-1,4-BENZOTHIAZIN-3-ONE
• CAS No.: 22726-30-3
• Molecular Formula: C9H9 N O2 S
• Molecular Weight: 195.24
• Hs Code.: 2934999090
• Mol file: 22726-30-3.mol

Synonyms:7-METHOXY-1,4-BENZOTHIAZIN-3(4H)-ONE;7-METHOXY-1,4-BENZOTHIAZIN-3-ONE;7-METHOXY 2H[1,4]BENZOTHIAZIN 3(4H)-ONE;7-Methoxy-1,4-Benzothiazine-3-One

Chemical Property of 7-METHOXY-1,4-BENZOTHIAZIN-3-ONE

Chemical Property:

• Vapor Pressure: 1.81E-06mmHg at 25°C
• Melting Point: 183-187 °C(lit.)
• Refractive Index: 1.6
• Boiling Point: 395.7°Cat760mmHg
• PKA: 12.41±0.20(Predicted)
• Flash Point: 193.1°C
• PSA: 63.63000
• Density: 1.282g/cm³
• LogP: 1.87740
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

7-Methoxy-1,4-benzothiazin-3-one ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-METHOXY-1,4-BENZOTHIAZIN-3-ONE

There total 11 articles about 7-METHOXY-1,4-BENZOTHIAZIN-3-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

chloroacetyl chloride (79-04-9) + 2-amino-5-methoxy-thiophenol (6274-29-9) → 7-methoxy-2H-benzo[b][1,4]thiazin-3(4H)-one (22726-30-3)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; In acetonitrile; at 0 ℃; Reflux;

DOI:10.1248/cpb.58.326

Reference yield: 90.0%

ethyl bromoacetate (105-36-2) + 2-amino-5-methoxy-thiophenol (6274-29-9) → 7-methoxy-2H-benzo[b][1,4]thiazin-3(4H)-one (22726-30-3)

Guidance literature:

With 1-octyl-3-methyl-3H-imidazolium nitrate; at 20 ℃; for 0.25h; Mechanism; Green chemistry;

DOI:10.1080/00397911.2012.687422

Reference yield: 62.0%

chloroacetic acid ethyl ester (105-39-5) + 6-methoxy-3H-benzo[d][1,2,3]dithiazole 2-oxide (73011-26-4) → 7-methoxy-2H-benzo[b][1,4]thiazin-3(4H)-one (22726-30-3)

Guidance literature:

With triethylamine; In methanol; water; for 0.333333h; Heating;

upstream raw materials:

4-methoxy-aniline

chloroacetic acid

chloroacetyl chloride

2-amino-5-methoxy-thiophenol

Downstream raw materials:

7-hydroxy-3,4-dihydro-3-oxo-2H(1,4)benzothiazine

N-cyclohexyl-N-methyl-4-[(2,3-dihydro-3-oxo-2H-1,4-benzothiazin-7-yl)oxy]butyramide

4-[2-(2,4-difluorophenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl]-7-methoxy-4H-benzo[1,4]thiazin-3-one

4-[2-(4-fluorophenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl]-7-methoxy-4H-benzo[1,4]thiazin-3-one

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