tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid

Base Information

Chemical Name:tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid
CAS No.:1393477-64-9
Molecular Formula:C₂₉H₄₂N₄O₆
Molecular Weight:542.676
Hs Code.:

Synonyms:tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid

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Chemical Property of tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid

Chemical Property:

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Technology Process of tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid

There total 3 articles about tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1083175-01-2
tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate

: 1393477-64-9
tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.5h;

Reference yield:

: 24277-39-2
N-tert-butoxycarbonyl glutamic acid tert-butyl ester

: 1393477-64-9
tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: dmap; triethylamine / acetonitrile / 2 h / 20 °C

3.1: diisobutylaluminium hydride / diethyl ether; tetrahydrofuran / -78 °C / Inert atmosphere

4.1: acetic acid / dichloromethane / 1 h / 0 °C

4.2: 20 °C

5.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

With hydrogenchloride; dmap; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 129241-89-0
tert-butyl (2S)-2-{bis[(tert-butoxy)carbonyl]amino}-5-oxopentanoate

: 1393477-64-9
tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

With hydrogenchloride; acetic acid; In dichloromethane; ethyl acetate;