benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate

Base Information

Chemical Name:benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate
CAS No.:275356-29-1
Molecular Formula:C₂₀H₁₉NO₅
Molecular Weight:353.375
Hs Code.:

Synonyms:benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate

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Chemical Property of benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate

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Technology Process of benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate

There total 5 articles about benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 194094-95-6
N-allyl-N-benzyloxycarbonyl-2-iodoaniline

: 275356-29-1
benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; benzene; at 65 ℃; for 18h; under 82745.9 Torr;
DOI:10.1021/ol0057030

Reference yield: 60.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 194094-95-6
N-allyl-N-benzyloxycarbonyl-2-iodoaniline

: 275356-29-1
benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate

: 3-methoxycarbonylmethyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester

: 2-(allyl-benzyloxycarbonyl-amino)-benzoic acid methyl ester

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; benzene; at 60 ℃; for 18h; under 82743.7 Torr;
DOI:10.1021/jo005703d

Reference yield:

: 615-43-0
2-iodophenylamine

: 275356-29-1
benzyl 3-(2-methoxy-2-oxoethyl)-4-oxo-3,4-dihydro-1(2H)-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / 1N NaOH / H₂O / 0.5 h / 20 °C

2: 93 percent / NaH / tetrahydrofuran / 19 h / 0 - 20 °C

3: 60 percent / Et₃N / PdCl₂(PPh₃)2 / benzene; acetonitrile / 18 h / 60 °C / 82743.7 Torr

With sodium hydroxide; sodium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; acetonitrile; benzene;
DOI:10.1021/jo005703d