(2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Base Information

Chemical Name:(2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine
CAS No.:1215007-34-3
Molecular Formula:C₂₀H₂₀F₃NO₃
Molecular Weight:379.379
Hs Code.:

Synonyms:(2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

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Technology Process of (2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

There total 1 articles about (2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 904296-01-1
(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

: 100-52-7
benzaldehyde

: 1215007-33-2
(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: 1215007-34-3
(2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: (2S,4R)-3-[anti-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

benzaldehyde; In dichloromethane; at -78 - 20 ℃; for 3h; Inert atmosphere;

With water; dihydrogen peroxide; In methanol; dichloromethane; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.jfluchem.2009.06.020