(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Base Information

Chemical Name:(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine
CAS No.:1215007-33-2
Molecular Formula:C₂₀H₂₀F₃NO₃
Molecular Weight:379.379
Hs Code.:

Synonyms:(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Suppliers and Price of (2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

There total 2 articles about (2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 904296-01-1
(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

: 100-52-7
benzaldehyde

: 1215007-33-2
(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: 1215007-34-3
(2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: (2S,4R)-3-[anti-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

benzaldehyde; In dichloromethane; at -78 - 20 ℃; for 3h; Inert atmosphere;

With water; dihydrogen peroxide; In methanol; dichloromethane; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.jfluchem.2009.06.020

Reference yield: 66.0%

: 904296-01-1
(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

: 100-52-7
benzaldehyde

: 1215007-33-2
(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: (2S,4R)-3-[anti-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: (2S,4R)-3-[anti-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at -78 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.jfluchem.2009.06.020

Reference yield: 72.0%

: 1215007-33-2
(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

: 1215007-35-4
(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanal

: 203176-56-1
(2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine; With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃;

With water; ammonium chloride; In diethyl ether; at -10 - 20 ℃;
DOI:10.1016/j.jfluchem.2009.06.020