(1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone

Base Information

Chemical Name:(1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone
CAS No.:1429022-29-6
Molecular Formula:C₂₂H₂₃FN₄O
Molecular Weight:378.449
Hs Code.:

Synonyms:(1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone

Chemical Property:

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Technology Process of (1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone

There total 7 articles about (1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1252765-77-7
2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone

: 1429022-29-6
(1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone

Guidance literature:: With triethylamine; In methanol; for 96h;

Reference yield:

: 1011-65-0
5-methoxycarbonylindole

: 1429022-29-6
(1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; copper(l) iodide / 2.5 h / 220 °C / Microwave irradiation

2: lithium hydroxide / tetrahydrofuran; water / 18 h / 55 °C / Inert atmosphere

3: triethylamine; HATU / dichloromethane / 16 h / 20 °C

4: triethylamine / methanol / 96 h

With copper(l) iodide; potassium carbonate; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1252779-85-3
1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone

: 1429022-29-6
(1-(4-fluorophenyl)-1H-indol-5-yl)(3-(piperazin-1-yl)azetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: carbonochloridic acid 1-chloro-ethyl ester; methanol / dichloromethane / 2.5 h / 0 °C / Inert atmosphere; Reflux

2: triethylamine; HATU / dichloromethane / 16 h / 20 °C

3: triethylamine / methanol / 96 h

With methanol; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; HATU; In methanol; dichloromethane;