4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde

Base Information

Chemical Name:4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde
CAS No.:1605281-04-6
Molecular Formula:C₂₄H₄₂O₄Si₂
Molecular Weight:450.766
Hs Code.:

Synonyms:4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde

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Chemical Property of 4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde

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Technology Process of 4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde

There total 6 articles about 4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1605281-03-5
4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

: 1605281-04-6
4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1605281-02-4
4-(3,5-dihydroxyphenyl)tetrahydro-2H-pyran-4-carbonitrile

: 1605281-04-6
4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 25 °C

2: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C / Inert atmosphere

With 1H-imidazole; diisobutylaluminium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 2-[3,5-bis(1-ethoxyethoxy)phenyl]acetonitrile

: 1605281-04-6
4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -16 °C / Inert atmosphere

1.2: 1 h / -16 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; methanol / 0.5 h / 25 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 25 °C

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C / Inert atmosphere

With 1H-imidazole; methanol; potassium hexamethylsilazane; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;