4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

Base Information

Chemical Name:4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile
CAS No.:1605281-03-5
Molecular Formula:C₂₄H₄₁NO₃Si₂
Molecular Weight:447.765
Hs Code.:

Synonyms:4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

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Chemical Property of 4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

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Technology Process of 4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

There total 5 articles about 4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1605281-02-4
4-(3,5-dihydroxyphenyl)tetrahydro-2H-pyran-4-carbonitrile

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1605281-03-5
4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

Reference yield:

: 2-[3,5-bis(1-ethoxyethoxy)phenyl]acetonitrile

: 1605281-03-5
4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -16 °C / Inert atmosphere

1.2: 1 h / -16 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; methanol / 0.5 h / 25 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 25 °C

With 1H-imidazole; methanol; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 58459-40-8
2-(3,5-dihydroxyphenyl)acetonitrile

: 1605281-03-5
4-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / diethyl ether / 1 h / 0 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -16 °C / Inert atmosphere

2.2: 1 h / -16 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid; methanol / 0.5 h / 25 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 25 °C

With 1H-imidazole; methanol; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;