3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one

Base Information

• Chemical Name: 3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one
• CAS No.: 1609627-34-0
• Molecular Formula: C₂₁H₁₇N₅O₄
• Molecular Weight: 403.397
• Mol file: 1609627-34-0.mol

Synonyms:3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one

Chemical Property of 3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one

There total 2 articles about 3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(E-)-N-methyl-1-(methylthio)-2-nitroethanamine (61832-41-5) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + edaravone (89-25-8) → 3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one (1609627-34-0)

Guidance literature:

With indium(III) chloride; In ethanol; for 6h; Reagent/catalyst; Solvent; Time; regioselective reaction; Reflux; Green chemistry;

DOI:10.1055/s-0033-1340666

Reference yield: 85.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + edaravone (89-25-8) + methylamine (74-89-5) + 1,1-di(methylsulfanyl)-2-nitroethylene (13623-94-4) → 3'-methyl-6'-(methylamino)-5'-nitro-1'-phenyl-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one (1609627-34-0)

Guidance literature:

methylamine; 1,1-di(methylsulfanyl)-2-nitroethylene; In ethanol; at 20 ℃; for 4h;

indole-2,3-dione; edaravone; In ethanol; for 8h;

DOI:10.1039/c9ra03214b

upstream raw materials:

(E-)-N-methyl-1-(methylthio)-2-nitroethanamine

indole-2,3-dione

edaravone

methylamine