1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone

Base Information

Chemical Name:1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone
CAS No.:1378382-92-3
Molecular Formula:C₁₅H₂₂BrClO₂Si
Molecular Weight:377.781
Hs Code.:

Synonyms:1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone

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Chemical Property of 1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone

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Technology Process of 1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone

There total 3 articles about 1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 67442-07-3
2-chloro-N-methoxy-N-methylacetamide

: 1378382-90-1
(2-bromo-5-iodobenzyloxy)(tert-butyl)dimethylsilane

: 1378382-92-3
1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone

Guidance literature:: (2-bromo-5-iodobenzyloxy)(tert-butyl)dimethylsilane; With TurboGrignard; In tetrahydrofuran; at -20 ℃; for 0.5h; Inert atmosphere;

2-chloro-N-methoxy-N-methylacetamide; In tetrahydrofuran; at -20 - 20 ℃; for 2h;

Reference yield:

: 25252-00-0
2-bromo-5-iodobenzoic acid

: 1378382-92-3
1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: diazomethyl-trimethyl-silane / dichloromethane; hexanes; methanol / 12 h / 20 °C

1.2: 122 h / 20 °C

1.3: 2 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

2.2: 2 h / -20 - 20 °C

With TurboGrignard; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; hexanes; dichloromethane;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1378382-92-3
1-(4-bromo-3-((tert-butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: diazomethyl-trimethyl-silane / dichloromethane; hexanes; methanol / 12 h / 20 °C

1.2: 122 h / 20 °C

1.3: 2 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

2.2: 2 h / -20 - 20 °C

With TurboGrignard; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; hexanes; dichloromethane;