(S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate

Base Information

• Chemical Name: (S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate
• CAS No.: 1346004-19-0
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Mol file: 1346004-19-0.mol

Synonyms:(S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate

Chemical Property of (S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate

There total 2 articles about (S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-carboethoxypentanal (27983-42-2) + (S)-1-(4-methoxyphenyl)ethylamine (6298-96-0,22038-86-4,35600-82-9,41851-59-6) → (S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate (1346004-19-0)

Guidance literature:

5-carboethoxypentanal; With magnesium sulfate; In dichloromethane; for 0.0833333h; Inert atmosphere;

(S)-1-(4-methoxyphenyl)ethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol202750u

Reference yield:

6-hydroxy-hexanoic acid ethyl ester (5299-60-5) → (S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate (1346004-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With magnesium sulfate; pyridinium chlorochromate; In dichloromethane;

DOI:10.1021/ol202750u

Reference yield: 44.0%

(S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate (1346004-19-0) → (1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one (1346004-53-2)

Guidance literature:

With 15-crown-5; sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 8h; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol202750u

upstream raw materials:

6-hydroxy-hexanoic acid ethyl ester

5-carboethoxypentanal

(S)-1-(4-methoxyphenyl)ethylamine

Downstream raw materials:

(1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate

trans-ethyl 2-aminocyclopentanecarboxylate