FMOC-METRP(BOC)-OH

Base Information

• Chemical Name: FMOC-METRP(BOC)-OH
• CAS No.: 197632-75-0
• Molecular Formula: C₃₂H₃₂N₂O₆
• Molecular Weight: 540.616
• Mol file: 197632-75-0.mol

Synonyms:Fmoc-metrp(boc)-OH;N-alpha-(9-Fluorenylmethoxycarbonyl)-N-alpha-methyL-N-in-t-butoxycarbonyl-L-tryptophan;

Chemical Property of FMOC-METRP(BOC)-OH

Chemical Property:

• Boiling Point: 710.9±70.0 °C(Predicted)
• PKA: 3.73±0.10(Predicted)
• PSA: 98.07000
• Density: 1.26 g/cm³
• LogP: 6.30110
• Storage Temp.: -15°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-?N-?Me-?Trp(Boc)?-?OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fmoc-?N-?Me-?Trp(Boc)?-?OH is a protected N-methyl tryptophan.

Technology Process of FMOC-METRP(BOC)-OH

There total 1 articles about FMOC-METRP(BOC)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) + (2S)-2-amino-3-(1-tert-butoxycarbonylindol-3-yl)propanoic acid (146645-63-8) → 1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-tryptophan (197632-75-0)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(97)01774-7

Reference yield:

9H-fluoren-9-ylmethyl N-[[2-(3-formylphenyl)phenyl]methyl]carbamate + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + Fmoc-Orn(Boc)-OH (109425-55-0,118476-89-4) + 1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-tryptophan (197632-75-0) → C52H73N7O10

Guidance literature:

1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-tryptophan; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

With piperidine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

9H-fluoren-9-ylmethyl N-[[2-(3-formylphenyl)phenyl]methyl]carbamate; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-Orn(Boc)-OH; Further stages;

upstream raw materials:

methanol

(fluorenylmethoxy)carbonyl chloride

(2S)-2-amino-3-(1-tert-butoxycarbonylindol-3-yl)propanoic acid