2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide

Base Information

• Chemical Name: 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide
• CAS No.: 299931-16-1
• Molecular Formula: C₂₈H₃₁F₃N₄O₈
• Molecular Weight: 608.571
• Mol file: 299931-16-1.mol

Synonyms:2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide

Chemical Property of 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide

There total 3 articles about 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-hydroxyphthalimide (524-38-9) + 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl bromide (299931-15-0) → 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide (299931-16-1)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.1021/jo000414a

Reference yield:

2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde (299931-13-8) → 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide (299931-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / ethanol / 0.5 h / 0 °C

2: 3.62 g / CBr₄; PPh₃; K₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

3: 85 percent / K₂CO₃ / dimethylsulfoxide / 12 h / 20 °C

With sodium tetrahydroborate; carbon tetrabromide; potassium carbonate; triphenylphosphine; In ethanol; dichloromethane; dimethyl sulfoxide; 1: Reduction / 2: Substitution / 3: Condensation;

DOI:10.1021/jo000414a

Reference yield:

2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl alcohol (299931-14-9) → 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide (299931-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.62 g / CBr₄; PPh₃; K₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: 85 percent / K₂CO₃ / dimethylsulfoxide / 12 h / 20 °C

With carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; dimethyl sulfoxide; 1: Substitution / 2: Condensation;

DOI:10.1021/jo000414a

upstream raw materials:

N-hydroxyphthalimide

2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl bromide

2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde

2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl alcohol