(S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester
CAS No.:760980-00-5
Molecular Formula:C₄₄H₆₀BNO₁₀Si
Molecular Weight:801.858
Hs Code.:

(S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Synonyms:(S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Chemical Property of (S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Technology Process of (S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

There total 7 articles about (S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 73183-34-3
bis(pinacol)diborane

: 843663-65-0
(S)-4-{3-[(2S,3R)-7-Bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 760980-00-5
(S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 85 ℃; for 6h;
DOI:10.1021/ja040091q

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 760980-00-5
(S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / imidazole / dimethylformamide / 6 h / 25 °C

2: 81 percent / Pd(diphenylphosphinoferrocene)Cl₂*CH₂Cl₂; KOAc / dimethylsulfoxide / 6 h / 85 °C

With 1H-imidazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja040091q

Reference yield:

: 760979-97-3
((S)-2-{3-[1-(3-Bromo-2-hydroxy-phenyl)-vinyl]-4-methoxy-phenyl}-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester

: 760980-00-5
(S)-4-{3-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxycarbonyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-3-yl]-4-methoxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / K₂CO₃ / acetone / 3 h / Heating

2: 96 percent / p-toluenesulfonic acid / acetone / 0.5 h / 25 °C

3: 84 percent / m-chloroperoxybenzoic acid; NaHCO₃ / CH₂Cl₂ / 8 h / 0 °C

4: 38 percent / KO-t-Bu / tetrahydrofuran; dimethylformamide / 0.08 h / -78 °C

5: 88 percent / imidazole / dimethylformamide / 6 h / 25 °C

6: 81 percent / Pd(diphenylphosphinoferrocene)Cl₂*CH₂Cl₂; KOAc / dimethylsulfoxide / 6 h / 85 °C

With 1H-imidazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja040091q