C₁₁H₁₅NO

Base Information

• Chemical Name: C₁₁H₁₅NO
• CAS No.: 1208117-72-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Mol file: 1208117-72-9.mol

Synonyms:C₁₁H₁₅NO

Chemical Property of C₁₁H₁₅NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₅NO

There total 5 articles about C₁₁H₁₅NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-methoxy-2-methylamino-benzoic acid methyl ester + methylmagnesium bromide (75-16-1) → C11H15NO (1208117-72-9)

Guidance literature:

5-methoxy-2-methylamino-benzoic acid methyl ester; methylmagnesium bromide; In diethyl ether; at 10 ℃; Inert atmosphere; Reflux;

With water; ammonium chloride; In diethyl ether; Inert atmosphere;

With iodine; In toluene; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/ol902949d

Reference yield:

2-isopropenyl-4-methoxyaniline (128368-43-4) + methyl iodide (74-88-4) → C11H15NO (1208117-72-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1002/adsc.202101130

Reference yield:

2-bromo-4-methoxyaniline (32338-02-6) → C11H15NO (1208117-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux

2.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In tetrahydrofuran; diethyl ether; water;

DOI:10.1002/anie.201808460

upstream raw materials:

methylmagnesium bromide

formaldehyd

2-isopropenyl-4-methoxyaniline

2-bromo-4-methoxyaniline

Downstream raw materials:

N-methyl(4-methoxy-2-(prop-1-en-2-yl)phenyl)carbamoyl cyanide