2,6-dichloro-N3-(((1r,4r)-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

Base Information Edit

Chemical Name:2,6-dichloro-N3-(((1r,4r)-4-methylcyclohexyl)methyl)pyridine-3,4-diamine
CAS No.:1658500-49-2
Molecular Formula:C₁₃H₁₉Cl₂N₃
Molecular Weight:288.22
Hs Code.:
Mol file:1658500-49-2.mol

Synonyms:2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

Suppliers and Price of 2,6-dichloro-N3-(((1r,4r)-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2,6-dichloro-N3-(((1r,4r)-4-methylcyclohexyl)methyl)pyridine-3,4-diamine Edit

Chemical Property:

Purity/Quality:: 99%min ^*data from raw suppliers

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Technology Process of 2,6-dichloro-N3-(((1r,4r)-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

There total 13 articles about 2,6-dichloro-N3-(((1r,4r)-4-methylcyclohexyl)methyl)pyridine-3,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1235873-11-6
2,6-dichloro-3-iodopyridin-4-amine

: 35388-78-4
((trans)-4-methylcyclohexyl)methanamine

: 1658500-49-2
2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

Guidance literature:: With chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01524

Reference yield:

: 1658500-48-1
tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate

: 1658500-49-2
2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 45 ℃; for 15h;

Reference yield:

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 1658500-49-2
2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; nitric acid / water / 0 °C

2: sulfuric acid / 3 h / 100 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -20 - 20 °C

4: iron; water / ethanol / 10 h / 20 °C

5: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

6: hydrogenchloride / 1,4-dioxane / 15 h / 45 °C

With hydrogenchloride; sulfuric acid; water; nitric acid; sodium tris(acetoxy)borohydride; iron; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;