3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester

Base Information

• Chemical Name: 3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester
• CAS No.: 244608-08-0
• Molecular Formula: C₂₁H₁₇IO₄
• Molecular Weight: 460.268
• Mol file: 244608-08-0.mol

Synonyms:3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester

Chemical Property of 3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester

There total 6 articles about 3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methanol (67-56-1) + 3-Benzyloxy-4-iodo-5-(3-methoxy-2-vinyl-benzoyloxy)-benzoic acid benzyl ester (244608-10-4) → 3,4-Dimethoxy-3H-isobenzofuran-1-one + 3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester (244608-08-0)

Guidance literature:

methanol; 3-Benzyloxy-4-iodo-5-(3-methoxy-2-vinyl-benzoyloxy)-benzoic acid benzyl ester; With ozone; In dichloromethane;

With triphenylphosphine; In dichloromethane;

DOI:10.1016/S0040-4020(02)00096-0

Reference yield: 33.0%

3-Benzyloxy-4-iodo-5-(3-methoxy-2-vinyl-benzoyloxy)-benzoic acid benzyl ester (244608-10-4) → 3-hydroxy-4-methoxy-1(3H)-isobenzofuranone (18713-43-4) + 3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester (244608-08-0) + 3-Benzyloxy-5-(2-formyl-3-methoxy-benzoyloxy)-4-iodo-benzoic acid benzyl ester

Guidance literature:

3-Benzyloxy-4-iodo-5-(3-methoxy-2-vinyl-benzoyloxy)-benzoic acid benzyl ester; In dichloromethane;

With triphenylphosphine; In dichloromethane;

DOI:10.1016/S0040-4020(02)00096-0

Reference yield: 28.0%

benzyl bromide (100-39-0) + 3,5-dihydroxy-4-iodobenzoic acid benzyl ester (302836-47-1) → 3,5-dihydroxybenzoic acid benzyl ester (101508-94-5) + 3-benzyloxy-5-hydroxy-4-iodobenzoic acid benzyl ester (244608-08-0) + 3,5-bis-benzyloxy-4-iodo-benzoic acid benzyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/jo000750r

upstream raw materials:

benzyl bromide

3,5-dihydroxy-4-iodobenzoic acid benzyl ester

methanol

3-Benzyloxy-4-iodo-5-(3-methoxy-2-vinyl-benzoyloxy)-benzoic acid benzyl ester

Downstream raw materials:

3-Benzyloxy-5-(3-benzyloxy-2-vinyl-benzoyloxy)-4-iodo-benzoic acid benzyl ester

3-Benzyloxy-4-iodo-5-(3-methoxy-2-vinyl-benzoyloxy)-benzoic acid benzyl ester