2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

Base Information

Chemical Name:2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine
CAS No.:160905-59-9
Molecular Formula:C₃₉H₆₁FN₆O₇Si₂
Molecular Weight:801.119
Hs Code.:

Synonyms:2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

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Chemical Property of 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

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Technology Process of 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

There total 8 articles about 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 115012-52-7
1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine

: 142741-95-5
3',5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-6-N-pivaloyladenosine

: 160905-59-9
2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

Guidance literature:: With mesitylene sulfonic acid; In tetrahydrofuran; acetonitrile;

Reference yield:

: 69304-45-6
3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

: 160905-59-9
2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine / 1) 30 min, room temperature; 2) 90 min, room temperature

2: toluene-p-sulfonic acid monohydrate / CH₂Cl₂; dioxane / 0.03 h

3: 86.3 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

With pyridine; mesitylene sulfonic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 160905-59-9
2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine / 1) 30 min, room temperature; 2) 90 min, room temperature

2: toluene-p-sulfonic acid monohydrate / CH₂Cl₂; dioxane / 0.03 h

3: 86.3 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

With pyridine; mesitylene sulfonic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;