N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide
CAS No.:1608129-06-1
Molecular Formula:C₂₀H₂₂ClFN₆O₃
Molecular Weight:448.884
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Suppliers and Price of N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

There total 7 articles about N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: N-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2-5-oxadiazole-3-carboximidoyl chloride hydrochloride

: 1608129-06-1
N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: In ethanol; for 5h; Reflux;

Reference yield:

: 702-24-9
4-methoxy-N-methylbenzylamine

: 1608129-06-1
N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 1 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - 20 °C

2.2: -10 °C

3.1: triethylamine / ethyl acetate; tetrahydrofuran / 1.5 h / 25 °C

4.1: potassium hydroxide / ethylene glycol / 2 h / 135 °C

5.1: sodium chloride; sodium nitrite; hydrogenchloride; acetic acid / water / 2.75 h / -2 - 20 °C / Cooling with ice

6.1: ethanol / 5 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium chloride; potassium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; water; ethylene glycol; ethyl acetate; toluene;

Reference yield:

: 1608129-03-8
4-amino-N'-hydroxy-N-(2-{[4-methoxybenzyl](methyl)amino}ethyl)-1,2,5-oxadiazole-3-carboximidamide

: 1608129-06-1
N-(3-chloro-4-fluorophenyl)-N'-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethylene glycol / 2 h / 135 °C

2: sodium chloride; sodium nitrite; hydrogenchloride; acetic acid / water / 2.75 h / -2 - 20 °C / Cooling with ice

3: ethanol / 5 h / Reflux

With hydrogenchloride; acetic acid; sodium chloride; potassium hydroxide; sodium nitrite; In ethanol; water; ethylene glycol;