4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Base Information

Chemical Name:4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS No.:1608129-01-6
Molecular Formula:C₁₂H₁₅ClFN₇O₄S
Molecular Weight:407.813
Hs Code.:

Synonyms:4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

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Chemical Property of 4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

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Technology Process of 4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

There total 7 articles about 4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1608129-09-4
N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

: 1608129-01-6
4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: With water; sodium hydroxide; at 19 - 29 ℃; for 1h;

Reference yield:

: N-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2-5-oxadiazole-3-carboximidoyl chloride hydrochloride

: 1608129-01-6
4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 5 h / Reflux

2: tetrahydrofuran / 1.75 h / Reflux

3: sodium hydrogencarbonate; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 4 h / 0 - 45 °C

4: SULFAMIDE; pyridine / 2.5 h / 100 °C

5: water; sodium hydroxide / 1 h / 19 - 29 °C

With pyridine; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydrogencarbonate; SULFAMIDE; sodium hydroxide; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;

Reference yield:

: 1608129-04-9
N'-hydroxy-4-({2-[(4-methoxybenzyl)(methyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide

: 1608129-01-6
4-(2-[(aminosulfonyl)(methyl)amino]ethylamino)-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium chloride; sodium nitrite; hydrogenchloride; acetic acid / water / 2.75 h / -2 - 20 °C / Cooling with ice

2: ethanol / 5 h / Reflux

3: tetrahydrofuran / 1.75 h / Reflux

4: sodium hydrogencarbonate; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 4 h / 0 - 45 °C

5: SULFAMIDE; pyridine / 2.5 h / 100 °C

6: water; sodium hydroxide / 1 h / 19 - 29 °C

With pyridine; hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hydrogencarbonate; SULFAMIDE; acetic acid; sodium chloride; sodium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane;