N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

Base Information

Chemical Name:N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide
CAS No.:1608129-09-4
Molecular Formula:C₁₃H₁₃ClFN₇O₅S
Molecular Weight:433.808
Hs Code.:

Synonyms:N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

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Chemical Property of N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

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Technology Process of N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

There total 6 articles about N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(3-chloro-4-fluorophenyl)-3-(4-((2-(methylamino)ethyl)amino)-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5(4H)-one hydrochloride

: 1608129-09-4
N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

Guidance literature:: With pyridine; SULFAMIDE; at 100 ℃; for 2.5h;

Reference yield:

: 1608129-03-8
4-amino-N'-hydroxy-N-(2-{[4-methoxybenzyl](methyl)amino}ethyl)-1,2,5-oxadiazole-3-carboximidamide

: 1608129-09-4
N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / ethylene glycol / 2 h / 135 °C

2: sodium chloride; sodium nitrite; hydrogenchloride; acetic acid / water / 2.75 h / -2 - 20 °C / Cooling with ice

3: ethanol / 5 h / Reflux

4: tetrahydrofuran / 1.75 h / Reflux

5: sodium hydrogencarbonate; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 4 h / 0 - 45 °C

6: SULFAMIDE; pyridine / 2.5 h / 100 °C

With pyridine; hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate; SULFAMIDE; acetic acid; sodium chloride; potassium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; water; ethylene glycol; 1,2-dichloro-ethane;

Reference yield:

: N-hydroxy-4-(2-[(4-methoxybenzyl)(methyl)amino]ethylamino)-1,2-5-oxadiazole-3-carboximidoyl chloride hydrochloride

: 1608129-09-4
N'-[2-({4-[4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]-N-methylaminosulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 5 h / Reflux

2: tetrahydrofuran / 1.75 h / Reflux

3: sodium hydrogencarbonate; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 4 h / 0 - 45 °C

4: SULFAMIDE; pyridine / 2.5 h / 100 °C

With pyridine; carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate; SULFAMIDE; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;