2-(4-Formyl-2-methoxyphenoxy)acetamide

Base Information

• Chemical Name: 2-(4-Formyl-2-methoxyphenoxy)acetamide
• CAS No.: 186685-89-2
• Molecular Formula: C10H11 N O4
• Molecular Weight: 209.202
• Hs Code.: 2924299090
• European Community (EC) Number: 672-088-4
• DSSTox Substance ID: DTXSID00346238
• Wikidata: Q82119145
• Mol file: 186685-89-2.mol

Synonyms:2-(4-formyl-2-methoxyphenoxy)acetamide;186685-89-2;2-(4-Formyl-2-methoxy-phenoxy)-acetamide;2-(4-Formyl-2-methoxy-phenoxy)acetamide;Oprea1_215052;Oprea1_702886;SCHEMBL2556186;DTXSID00346238;BBL014052;MFCD01050452;STK155582;AKOS000202383;AM85641;UPCMLD0ENAT5235926:001;AS-10400;BB 0243297;CS-0150511;FT-0677740;EN300-09336;D94909;2-{[4-formyl-2-(methyloxy)phenyl]oxy}acetamide;A880621;AG-690/11571186;Z19660630

Chemical Property of 2-(4-Formyl-2-methoxyphenoxy)acetamide

Chemical Property:

• Vapor Pressure: 2.32E-08mmHg at 25°C
• Melting Point: 84-85 °C(Solv: benzene (71-43-2))
• Refractive Index: 1.569
• Boiling Point: 452°C at 760 mmHg
• PKA: 15.30±0.40(Predicted)
• Flash Point: 263.3°C
• PSA: 78.62000
• Density: 1.257g/cm³
• LogP: 1.07210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 209.06880783
• Heavy Atom Count: 15
• Complexity: 232

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Formyl-2-methoxyphenoxy)acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C=O)OCC(=O)N

Technology Process of 2-(4-Formyl-2-methoxyphenoxy)acetamide

There total 1 articles about 2-(4-Formyl-2-methoxyphenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

vanillin (121-33-5,8014-42-4) + Chloroacetamide (79-07-2) → 2-(4-formyl-2-methoxyphenoxy)acetamide (186685-89-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; Reflux;

DOI:10.1007/s11172-015-0875-9

Reference yield: 93.0%

2-(4-formyl-2-methoxyphenoxy)acetamide (186685-89-2) + 4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) + malononitrile (109-77-3) → 2-[4-(2-amino-3-cyano-5-oxo-4H,5H-pyrano[3,2-c]chromen-4-yl)-2-methoxy-phenoxy]-acetamide (340812-14-8)

Guidance literature:

With triethylamine; In ethanol; for 0.0833333h; Heating;

DOI:10.1007/s11172-005-0346-9

Reference yield: 62.0%

2-(4-formyl-2-methoxyphenoxy)acetamide (186685-89-2) + rhodanine 3-acetic acid (5718-83-2) → {5-[(4-carbamoylmethoxy-3-methoxyphenyl)methylidene]-4-oxo-2-thioxothiazolidin-3-yl}acetic acid

Guidance literature:

With sodium acetate; acetic acid; Reflux;

DOI:10.1016/j.ejmech.2014.05.003

upstream raw materials:

vanillin

Chloroacetamide

Downstream raw materials:

2-[4-(2-amino-3-cyano-5-oxo-4H,5H-pyrano[3,2-c]chromen-4-yl)-2-methoxy-phenoxy]-acetamide

3-amino-3-(4-carbamoylmethoxy-3-methoxy-phenyl)-propionic acid

Refernces

• 1、 Maccari, Rosanna,Vitale, Rosa Maria,Ottanà, Rosaria,Rocchiccioli, Marco,Marrazzo, Agostino,Cardile, Venera,Graziano, Adriana Carol Eleonora,Amodeo, Pietro,Mura, Umberto,Del Corso, Antonella. "Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents". . p. 1 - 14. Retrieved 2014/06/09.