syn-α-bromoacetophenone oxime

Base Information

• Chemical Name: syn-α-bromoacetophenone oxime
• CAS No.: 17082-14-3
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.062
• Mol file: 17082-14-3.mol

Synonyms:syn-α-bromoacetophenone oxime

Chemical Property of syn-α-bromoacetophenone oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of syn-α-bromoacetophenone oxime

There total 8 articles about syn-α-bromoacetophenone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

α-bromoacetophenone (70-11-1) → 2-bromo-1-phenyl-ethanone oxime (14181-72-7,17082-13-2,17082-14-3)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In methanol; at 70 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.12.062

Reference yield:

acetophenone (98-86-2) → 2-bromo-1-phenyl-ethanone oxime (14181-72-7,17082-13-2,17082-14-3)

Guidance literature:

acetophenone; With bromine;

With hydroxylamine;

DOI:10.1246/cl.2004.1274

Reference yield:

2-bromophenyl methyl ketone (2142-69-0) → 2-bromo-1-phenyl-ethanone oxime (14181-72-7,17082-13-2,17082-14-3)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In ethanol; water; at 20 ℃; for 24h;

DOI:10.1002/hlca.200900051

upstream raw materials:

α-bromoacetophenone

acetophenone

2-bromophenyl methyl ketone

acetylhydroxamic acid

Downstream raw materials:

3-(β-hydroxyimino-phenethyl)-pentane-2,4-dione

3-benzoyl-1-phenyl-pentane-1,4-dione-1-(Z)-oxime

7a-morpholin-4-yl-3-phenyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,2]oxazine

1-morpholino-4-phenyl-2-oxa-3-azabicyclo<4.4.0>dec-3-ene

Refernces

• 1、 Shen, Li-Wen,Wang, Zhen-Hua,You, Yong,Yuan, Wei-Cheng,Zhao, Jian-Qiang,Zhou, Ming-Qiang. "α-Nitrosostyrenes as Three-Atom Units for the (3+1) Cyclization Reaction: Facile Access to 2,3-Dihydrodiazete N-Oxides and Their Diversified Synthetic Conversions". . p. 1094 - 1099. Retrieved 2022/02/10.
• 2、 Zhao, Sen,Wang, Hang,Sun, Shaofa,Guo, Haibing,Chen, Zhiyu,Wang, Jian,Wang, Lu,Liang, Steven,Wang, Gangqiang. "An efficient synthesis of 2-isoxazolines from α-haloketone oximes and dimethyl sulfonium salts". supporting information. p. 382 - 385. Retrieved 2019/01/04.