6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Base Information

Chemical Name:6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide
CAS No.:1246609-60-8
Molecular Formula:C₃₂H₄₂N₈O₂
Molecular Weight:570.738
Hs Code.:

Synonyms:6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Suppliers and Price of 6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

There total 10 articles about 6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246610-02-5
bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

: 1246609-60-8
6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Guidance literature:: bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

With sodium hydrogencarbonate;

Reference yield:

: 53292-90-3
cis-4-tert-butoxycarbonylaminocyclohexane-1-ylcarboxylic acid

: 1246609-60-8
6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 48 h / 20 °C

2.1: ethyl acetate; tetrahydrofuran / 4 h / 0 °C

2.2: Cooling with ice

3.1: ethanol / 24 h / Reflux

4.1: sodium hydroxide; ethanol / 2 h / 20 °C

4.2: pH 5

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 24 h / 20 °C

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

7.1: dmap / tetrahydrofuran / 0.25 h / 20 °C

8.1: dmap; triethylamine / tetrahydrofuran / 3 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With hydrogenchloride; dmap; ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 3.1: Bohlman-Rahtz Reaction;

Reference yield:

: ethyl 3-amino-3-anilinoacrylate

: 1246609-60-8
6-((1s,4s)-4-(3-((6-aminopyridin-3-yl)methyl)ureido)cyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 24 h / Reflux

2.1: sodium hydroxide; ethanol / 2 h / 20 °C

2.2: pH 5

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 24 h / 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

5.1: dmap / tetrahydrofuran / 0.25 h / 20 °C

6.1: dmap; triethylamine / tetrahydrofuran / 3 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With hydrogenchloride; dmap; ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1.1: Bohlman-Rahtz Reaction;